Research Opportunity: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19)

Notice of Special Interest (NOSI): Availability of Emergency Competitive Revisions for Research on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19)


Notice Number: NOT-RM-20-015

Release Date: April 27, 2020
First Available Due Date: April 15, 2020
Expiration Date: June 20, 2020

Issued by Office of Strategic Coordination (Common Fund)

Purpose

The Office of Strategic Coordination (OSC), which manages the Common Fund, is issuing this Notice of Special Interest (NOSI) to stimulate innovative research on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the disease it causes, Coronavirus Disease 2019 (COVID-19). OSC seeks new, innovative perspectives and approaches to the prevention of, preparation for, or response to coronavirus SARS-CoV-2, domestically or internationally. The funding for this supplement is provided from the Coronavirus Aid, Relief, and Economic Security (CARES) Act, 2020.

OSC is therefore offering Emergency Competitive Revisions to active Common Fund grants and cooperative agreements addressing the research objectives described below.

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Can Mindfulness Evolve From Wellness Pursuit to Medical Treatment? | New York Times Magazine

Roughly a third of all adults in the United States have high blood pressure, a major risk factor for heart disease and stroke. It’s a condition that can be largely controlled with diet, exercise and medication, yet the Centers for Disease Control and Prevention estimates that only about half of the 75 million people who have high blood pressure manage to keep it in check. In November, Eric Loucks, director of the Mindfulness Center at the Brown University School of Public Health, and colleagues published a study in Plos One, a science journal, that put forward a possible solution: an eight-week mindfulness-based program.

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New NIH Adherence FOAs published

These new funding opportunities on Adherence direct people to SOBC resources and encourage their use:

Improving Patient Adherence to Treatment and Prevention Regimens to Promote Health

https://grants.nih.gov/grants/guide/pa-files/PA-18-722.html  –  R01

https://grants.nih.gov/grants/guide/pa-files/PA-18-723.html  – R21

 

This funding opportunity announcement (FOA) is being issued by the NIH Adherence Network through the Office of Behavioral and Social Sciences Research (OBSSR) with participation from multiple NIH Institutes and Centers. This FOA calls for research grant applications which address patient adherence to treatment and prevention regimens in healthcare to promote health outcomes. This FOA accepts applications that either propose or do not propose a clinical trial(s).

Applications under this FOA are encouraged, but not required, to apply approaches and tools developed under the NIH Common Fund’s Science of Behavior Change (SOBC) Program. These include: use-inspired basic research on mechanisms of change at multiple levels of analysis; assays for self-regulation, interpersonal processes and stress that have evidence as malleable targets for behavior change (see https://osf.io/zp7b4) developed under the SOBC program; and an experimental medicine approach which requires a clear a priori specification of the intended mechanistic target(s) of an intervention, and methods that test the degree to which an experimental manipulation or intervention engages those targets.

For more information about the SOBC program, please see: https://commonfund.nih.gov/behaviorchange.

 

Journal of Behaviour and Research Therapy, Special Issue on the Science of Behavior Change

Members of the SOBC research network collaborated on a newly published special issue in the Journal of Behaviour and Research Therapy titled, Special Issue on the Science of Behavior Change (Feb. 2018). This issue introduces readers to the SOBC network, provides examples of how the mechanistic, experimental-medicine approach to behavior change research is currently being implemented, and showcases emerging research within the network. The issue features seven papers focusing on the vital research of the network members. This work spans important and diverse topics that are each highly relevant to progress in the SOBC mission, including all of the following (and more): the ontology of self-regulation; the ingredients of mindfulness; the most promising stress response targets for interventions; self-efficacy, executive function, temporal discounting as mechanisms by which stress may affect health behaviors; coercive interpersonal relationships; self-regulation in children; and virtual reality measures of self-regulation. read more »

 

Aerobic Exercise May Improve Cognitive Symptoms of Alzheimer’s Disease

Exercise training may delay the decline in cognitive function that occurs in individuals who are at risk of or have Alzheimer’s disease, with aerobic exercise possibly having the most favorable effect, according to a review of 19 previous studies on the topic.

Approximately 5.3 million Americans are living with Alzheimer’s disease. Alzheimer’s-related medical costs in the United States are estimated to exceed $1.1 trillion by 2050 unless effective methods to prevent and treat Alzheimer’s disease are identified.

Exercise training is recommended as a cost-effective lifestyle therapeutic option to improve brain health in older adults, with improvements in cognitive function mediated by positive neurophysiological changes. read more »

 

Relevance of Social Networks for Adolescent Obesity

The idea that obesity is contagious and can be spread like a virus was a brilliant analogy that provided a convenient rubric for people to understand that obesity could be transmitted to other individuals. In this issue of JAMA Pediatrics, Datar and Nicosia present an innovative natural experiment to study whether adolescent and parental obesity spreads in social net- works. The ideal experiment to test whether multigenerational obesity is spread within a social network would be to randomize a group of non-obese parents with non-obese adolescent children to live in environments with a low or high proportion of families with obesity. This thought experiment would be difficulty to implement, but the natural experiment by Datar and Nicosia3 was a proxy for this format by studying 1519 military families who were assigned to relocate to counties with obesity rates that varied from 21% to 38%. Data on height and weight were collected via parental self-report, and Datar and Nicosia also measured height, weight, and body composition in a subset of 458 adolescents. They also collected objective and self-reported data on built environment, and had data on how long the families lived in the new community, and whether they lived on or off the military installation.

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