Members of the SOBC research network collaborated on a newly published special issue in the Journal of Behaviour and Research Therapy titled, Special Issue on the Science of Behavior Change (Feb. 2018). This issue introduces readers to the SOBC network, provides examples of how the mechanistic, experimental-medicine approach to behavior change research is currently being implemented, and showcases emerging research within the network. The issue features seven papers focusing on the vital research of the network members. This work spans important and diverse topics that are each highly relevant to progress in the SOBC mission, including all of the following (and more): the ontology of self-regulation; the ingredients of mindfulness; the most promising stress response targets for interventions; self-efficacy, executive function, temporal discounting as mechanisms by which stress may affect health behaviors; coercive interpersonal relationships; self-regulation in children; and virtual reality measures of self-regulation. Additionally, the special issue includes pieces about the goals of the SOBC mission from the perspective of NIH administrators as well as a systematic review that addresses the extent to which literature has investigated mechanisms that underlie the important and continuing problem of medication nonadherence.